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The antiepileptic effect of Gastrodiae Rhizoma through modulating overexpression of mTOR and attenuating astrogliosis in pilocarpine mice model.

Ka Lai YipChi Man KoonZi Yi ChenPing ChookPing Chung LeungSteven SchachterWai Hong LeungChung Tong MokHowan Leung
Published in: Epilepsia open (2019)
These results provide preclinical evidence to support the use of GR, which could suppress acute seizures and relieve pathological changes in pilocarpine-induced TLE mice. We demonstrated that the antiepileptic effects of GR could be accompanied by mTOR reduction and astrogliosis attenuation.
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