DNA Methylation based prognostic subtypes of chordoma tumors in tissue and plasma.
Jeffrey A ZuccatoVikas PatilSheila MansouriJeffrey C LiuFarshad NassiriYasin MamatjanAnkur ChakravarthyShirin KarimiJoao Paulo AlmeidaAnne-Laure BernatMohammed HasenOlivia SinghShahbaz KhanThomas KislingerNamita SinhaSébastien FroelichHoma Adle-BiassetteKenneth D AldapeDaniel D De CarvalhoGelareh ZadehPublished in: Neuro-oncology (2021)
Here, we show the first identification of prognostic epigenetic chordoma subtypes and first use of plasma methylome-based biomarkers to non-invasively diagnose and subtype chordomas. These results may transform patient management by allowing treatment aggressiveness to be balanced with patient risk according to prognosis.