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Do epigenetic clocks provide explanations for sex differences in lifespan? A cross-sectional twin study.

Anna KankaanpääAsko TolvanenPirkko SaikkonenAino HeikkinenEija K LaakkonenJaakko KaprioMiina OllikainenElina Sillanpää
Published in: The journals of gerontology. Series A, Biological sciences and medical sciences (2021)
Previously reported sex differences in lifespan are also evident in biological aging. Declining smoking prevalence among men is a plausible explanation for the narrowing of the difference in life expectancy between the sexes. Data generated by the epigenetic clocks may help in estimating the effects of lifestyle and environmental factors on aging and in predicting aging in future generations.
Keyphrases
  • dna methylation
  • gene expression
  • metabolic syndrome
  • risk factors
  • physical activity
  • cardiovascular disease
  • weight loss
  • big data
  • current status
  • deep learning