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MiRNA-146a polymorphism increases the odds of malaria in pregnancy.

Welmoed van LoonPrabhanjan P GaiLutz HamannGeorge Bedu-AddoFrank P Mockenhaupt
Published in: Malaria journal (2019)
These results indicate that SNP rs2910164 G > C is associated with increased odds for P. falciparum infection in first-time pregnant women who are considered to lack sufficient acquired immune responses against pregnancy-specific strains of P. falciparum. These findings suggest that miRNA-146a is involved in protective malarial immunity, and specifically in the innate component.
Keyphrases
  • immune response
  • pregnant women
  • pregnancy outcomes
  • preterm birth
  • plasmodium falciparum
  • escherichia coli
  • dendritic cells
  • toll like receptor
  • gene expression