NIR luminogen for low-temperature photothermal therapy by triggering HSP90α down-regulation.

Xinzhe YangKeke DingGuiquan ZhangPengbo HanRong HuZhiming Wang Anjun QinBen Zhong Tang

Published in: Chemical communications (Cambridge, England) (2023)

A near-infrared (NIR) luminogen TST was designed and used to efficiently trigger HSP90α protein knockdown through photo-thermal conversion based on a gene interference strategy, by which in vitro and in vivo tumor ablation were significantly acquired at low-temperature.

Keyphrases

heat shock protein
heat shock
photodynamic therapy
heat stress
drug release
fluorescence imaging
fluorescent probe
genome wide
copy number
protein protein
binding protein
amino acid
drug delivery
genome wide identification
gene expression
dna methylation
atrial fibrillation
transcription factor
catheter ablation