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Protein language models enable prediction of polyreactivity of monospecific, bispecific, and heavy-chain-only antibodies.

Xin YuKostika VangjeliAnusha PrakashMeha ChhayaSamantha J StanleyNoah CohenLili Huang
Published in: Antibody therapeutics (2024)
To our knowledge, this represents the first application of PLMs to predict assay data on bispecifics and VHH-Fcs.
Keyphrases
  • healthcare
  • electronic health record
  • high throughput
  • autism spectrum disorder
  • big data
  • protein protein
  • amino acid
  • binding protein
  • small molecule