Regioselective Construction of α,α-Disubstituted Allylic Amines by the Ruthenium-Catalyzed Allylic Amination of Tertiary Allylic Acetates.

The ruthenium-catalyzed regioselective allylic amination of tertiary allylic acetates with several types of amines has been accomplished. The reaction was effectively catalyzed by Cp*RuCl2/5,5'-dimethyl-2,2'-bipyridine or its related ruthenium catalyst systems, and α,α-disubstituted allylic amines were formed as a single regioisomer in moderate to high yields.