An efficient and facile strategy for trifluoromethylation and perfluoroalkylation of isoquinolines and heteroarenes.

An effective and regioselective strategy for trifluoromethylation and perfluoroalkylation of isoquinolines and heteroarenes was developed. By combination of TMSCnF2n+1 (n = 1, 2, 3) with PIFA, the method achieved the corresponding perfluoroalkylated products with broad functional group tolerance.