DYRK1B blockade promotes tumoricidal macrophage activity in pancreatic cancer.

Anna I BrichkinaMiriam EmsRoman SuezovRajeev SinghVeronika LutzFelix S R PicardAndrea NistThorsten StieweJohannes GraumannMichael DaudeWibke E DiederichFlorian FinkernagelHo-Ryun ChungDetlef K BartschKatrin RothCorinna KeberCarsten DenkertMagdalena HuberThomas M GressMatthias Lauth

Published in: Gut (2024)

In light of DYRK inhibitors currently entering clinical phase testing, our data thus provide a novel and clinically translatable approach targeting both the cancer cell compartment and its microenvironment.

Keyphrases

stem cells
electronic health record
adipose tissue
cancer therapy
big data
machine learning
drug delivery
data analysis