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DYRK1B blockade promotes tumoricidal macrophage activity in pancreatic cancer.

Anna I BrichkinaMiriam EmsRoman SuezovRajeev SinghVeronika LutzFelix S R PicardAndrea NistThorsten StieweJohannes GraumannMichael DaudeWibke E DiederichFlorian FinkernagelHo-Ryun ChungDetlef K BartschKatrin RothCorinna KeberCarsten DenkertMagdalena HuberThomas M GressMatthias Lauth
Published in: Gut (2024)
In light of DYRK inhibitors currently entering clinical phase testing, our data thus provide a novel and clinically translatable approach targeting both the cancer cell compartment and its microenvironment.
Keyphrases
  • stem cells
  • electronic health record
  • adipose tissue
  • cancer therapy
  • big data
  • machine learning
  • drug delivery
  • data analysis