Safety of [177Lu]Lu-NeoB treatment: a preclinical study characterizing absorbed dose and acute, early, and late organ toxicity.

Eline A M RuigrokMarjolein VerhoevenMark W KonijnenbergErik de BloisCorrina M A de RidderDebra C StuurmanLuisa BertarioneKatia RolfoMarion de JongSimone U Dalm

Published in: European journal of nuclear medicine and molecular imaging (2022)

In general, repeated administration of [177Lu]Lu-NeoB was tolerated. The most significant radiotoxic effects were found in the kidneys, similar to other clinically applied radioligands. The results of this study underline the potential of [177Lu]Lu-NeoB as a promising option for clinical therapy.

Keyphrases

liver failure
oxidative stress
risk assessment
cell therapy
hepatitis b virus
human health
combination therapy
extracorporeal membrane oxygenation