Very Low-Calorie Ketogenic Diet: A Potential Application in the Treatment of Hypercortisolism Comorbidities.
Valentina GuarnottaFabrizio EmanueleRoberta AmodeiCarla GiordanoPublished in: Nutrients (2022)
A very low-calorie ketogenic diet (VLCKD) is characterized by low daily caloric intake (less than 800 kcal/day), low carbohydrate intake (<50 g/day) and normoproteic (1-1.5 g of protein/kg of ideal body weight) contents. It induces a significant weight loss and an improvement in lipid parameters, blood pressure, glycaemic indices and insulin sensitivity in patients with obesity and type 2 diabetes mellitus. Cushing's syndrome (CS) is characterized by an endogenous or exogenous excess of glucocorticoids and shows many comorbidities including cardiovascular disease, obesity, type 2 diabetes mellitus and lipid disorders. The aim of this speculative review is to provide an overview on nutrition in hypercortisolism and analyse the potential use of a VLCKD for the treatment of CS comorbidities, analysing the molecular mechanisms of ketogenesis.
Keyphrases
- weight loss
- bariatric surgery
- glycemic control
- roux en y gastric bypass
- cardiovascular disease
- weight gain
- type diabetes
- body weight
- blood pressure
- gastric bypass
- physical activity
- metabolic syndrome
- insulin resistance
- cardiovascular risk factors
- body mass index
- risk assessment
- heart rate
- blood glucose
- high fat diet induced
- coronary artery disease
- skeletal muscle
- amino acid