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Impact of central nervous system involvement in AML on outcomes after allotransplant and utility of pretransplant cerebrospinal fluid assessment.

Shruti PremEshetu G AtenafuJose AvenaRhida BautistaArjun LawWilson LamFotios V MichelisDennis Dong Hwan KimAuro ViswabandyaJeffrey Howard LiptonJonas MattssonRajat Kumar
Published in: European journal of haematology (2019)
CNS-AML is not an independent risk factor for survival after allo-HCT, but can be associated with higher relapse rates. Pretransplant CSF assessment has low yield in detecting new CNS disease pretransplant in AML.
Keyphrases
  • cerebrospinal fluid
  • acute myeloid leukemia
  • allogeneic hematopoietic stem cell transplantation
  • blood brain barrier
  • acute lymphoblastic leukemia
  • cell proliferation
  • signaling pathway