ARHGEF37 overexpression promotes extravasation and metastasis of hepatocellular carcinoma via directly activating Cdc42.

Xin ZhangLiangliang RenJunhua WuRongni FengYunyang ChenRonggang LiMeimei WuMingzhu ZhengXing Gui WuWanjun LuoHongle HeYanming HuangMiaoling TangJun Li

Published in: Journal of experimental & clinical cancer research : CR (2022)

Our findings provide a new insight into the underlying mechanisms on the ARHGEF37 overexpression-mediated extravasation and pulmonary metastasis of HCC cells, and provided a potential therapeutic target for the prevention and treatment of HCC pulmonary metastasis.

Keyphrases

pulmonary hypertension
cell proliferation
induced apoptosis
transcription factor
signaling pathway
cell cycle arrest
cell cycle
oxidative stress
risk assessment
endoplasmic reticulum stress
climate change
replacement therapy