Side Effects 15 Years After Lymph Node Irradiation in Breast Cancer: Randomized EORTC Trial 22922/10925.
Philip M P PoortmansHenk StruikmansPeter De BrouwerCaroline WeltensCatherine FortpiedCarine KirkoveVolker BudachKarine Peignaux-CasasnovasFemke van der LeijErnest VonkMariacarla ValliGeertjan vanTienhovenNicola WeidnerGeorges NoelMatthias GuckenbergerEveline KoiterErik vanLimbergenAntoine EngelenAlain FourquetHarry Bartelinknull nullPublished in: Journal of the National Cancer Institute (2022)
The incidence of late pulmonary side effects was statistically significantly higher after IM-MS lymph node irradiation, as were some of the cardiac events, without a difference between left- and right-sided treatments. Absolute rates and differences were very low, without increased non-breast cancer-related mortality, even before introducing heart-sparing techniques.
Keyphrases
- lymph node
- phase iii
- phase ii
- risk factors
- open label
- double blind
- neoadjuvant chemotherapy
- clinical trial
- sentinel lymph node
- placebo controlled
- pulmonary hypertension
- multiple sclerosis
- study protocol
- mass spectrometry
- heart failure
- cardiovascular events
- ms ms
- left ventricular
- radiation induced
- robot assisted
- type diabetes
- radiation therapy
- cardiovascular disease
- squamous cell carcinoma
- coronary artery disease
- young adults
- minimally invasive