Inherited variants in XRCC2 and the risk of breast cancer.

Wojciech KluźniakDominika WokołorczykBogna RusakTomasz HuzarskiJacek GronwaldKlaudia StempaHelena RudnickaAniruddh KashyapTadeusz DębniakAnna JakubowskaMarcin LenerMarek SzwiecJoanna Tomiczek-SzwiecJoanna Jarkiewicz-TretynMagdalena CechowskaPaweł DomagałaAgata SzymiczekMaryam BagherzadehJan LubińskiSteven A NarodMohammad R AkbariCezary Cybulskinull null

Published in: Breast cancer research and treatment (2019)

XRCC2 c.96delT is a protein-truncating founder variant in Poland. There is no evidence that this mutation predisposes to breast cancer (and other cancers). It is premature to consider XRCC2 as a breast cancer-predisposing gene.

Keyphrases

dna repair
copy number
dna damage
genome wide
gene expression
dna methylation
oxidative stress
small molecule
amino acid
breast cancer risk
genome wide identification