Knockout of Zeb2 ameliorates progression of renal tubulointerstitial fibrosis in a mouse model of renal ischemia-reperfusion injury.
Satoshi InotaniYoshinori TaniguchiKeisyun NakamuraHirofumi NishikawaTatsuki MatsumotoTaro HorinoShimpei FujimotoShigetoshi SanoMotoko YanagitaYoshio TeradaPublished in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2021)
Zeb2 was upregulated in renal tissues in both mice and humans with AKI. Zeb2 regulates fibrotic pathways in the pathogenesis of AKI and AKI to CKD transition. Therefore, inhibition of Zeb2 could be a potential therapeutic strategy for AKI.
Keyphrases
- acute kidney injury
- epithelial mesenchymal transition
- long non coding rna
- mouse model
- ischemia reperfusion injury
- gene expression
- chronic kidney disease
- oxidative stress
- type diabetes
- signaling pathway
- idiopathic pulmonary fibrosis
- systemic sclerosis
- adipose tissue
- high fat diet induced
- insulin resistance
- wild type