Efficacy and safety of malarial prophylaxis with mefloquine during pregnancy in Kisangani, Democratic Republic of Congo: A randomized clinical trial.

Noël Labama Otuli Roland Marini Djang'eing'a Joris Losimba Likwela Jean-Didier Bosenge-Nguma Mike-Antoine Maindo AlongoAlbert Ahuka Ona LongombeBernard Mbutu MangoDiane M N BonoJohn L Mokili Jean-Pascal Manga Okenge

Published in: British journal of clinical pharmacology (2021)

Splitting dose and intake with a meal increased mefloquine tolerability while keeping its efficacy higher compared to sulfadoxine-pyrimethamine. Intermittent preventive treatment during pregnancy using mefloquine reduces the risk of placental malaria, maternal peripheral parasitaemia and low birth weight, compared to sulfadoxine-pyrimethamine. Thus, mefloquine is a good alternative to intermittent preventive treatment in pregnancy.

Keyphrases

low birth weight
plasmodium falciparum
preterm birth
preterm infants
human milk
high intensity
clinical trial
combination therapy
physical activity
birth weight
replacement therapy
gestational age