Login / Signup

Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia.

Changyu KangSanghyun JuJaejeong KimYunjin Jung
Published in: Pharmacological reports : PR (2022)
Under hypoxia, CQ-mediated sensitization of colon carcinoma HCT116 cells to 5-FU involves HIF-1 inhibition via ATR kinase suppression.
Keyphrases
  • endothelial cells
  • cell cycle arrest
  • induced apoptosis
  • protein kinase
  • dna damage response
  • signaling pathway
  • tyrosine kinase
  • cell death
  • endoplasmic reticulum stress
  • dna damage