Identification of potential mediators of the relationship between body mass index and colorectal cancer: a Mendelian randomization analysis.

Emmanouil C Bouras Dipender Gill Verena Zuber Neil MurphyNiki DimouKrasimira AleksandrovaSarah J LewisRichard M MartinJames YarmolinskyDemetrius AlbanesHermann BrennerSergi Castellví-BelAndrew T ChanIona ChengStephen GruberBethany Van GuelpenChristopher I LiLoic Le MarchandPolly A NewcombShuji OginoAndrew PellattStephanie L SchmitAlicja WolkAnna H WuUlrike PetersMarc J GunterKonstantinos K Tsilidis

Published in: International journal of epidemiology (2024)

The effect of BMI on CRC risk is possibly partly mediated through plasma IGF1, whereas the attenuation of the BMI-CRC association by smoking and PA may reflect confounding and shared underlying mechanisms rather than mediation.

Keyphrases

body mass index
weight gain
smoking cessation
binding protein
pi k akt
human health
physical activity
risk assessment
bioinformatics analysis
signaling pathway