Sequential implementation of DSC-MR perfusion and dynamic [18F]FET PET allows efficient differentiation of glioma progression from treatment-related changes.
Eike SteidlKarl-Josef LangenSarah Abu HmeidanNenad PolomacChristian P FilssNorbert GalldiksPhilipp LohmannFee KeilKatharina FilipskiFelix M MottaghyNadim Jon ShahJoachim P SteinbachElke HattingenGabriele D MaurerPublished in: European journal of nuclear medicine and molecular imaging (2020)
While marked hyperperfusion on PWI indicated TP, [18F]FET PET proved beneficial to discriminate TP from TRC when PWI remained inconclusive. Thus, our results highlight the clinical value of sequential use of PWI and [18F]FET PET, allowing an economical use of diagnostic methods. The impact of an IDH mutation needs further investigation.