Network Pharmacology-Based Approach to Investigate the Mechanisms of Hedyotis diffusa Willd. in the Treatment of Gastric Cancer.

Xinkui LiuJia-Rui WuDan ZhangKaihuan WangXiaojiao DuanZiqi MengXiaomeng Zhang

Published in: Evidence-based complementary and alternative medicine : eCAM (2018)

This study holistically illuminates the fact that the pharmacological mechanisms of HDW in GC might be strongly associated with its synergic modulation of apoptosis, cell cycle, differentiation, proliferation, migration, invasion, and angiogenesis.

Keyphrases

cell cycle
cell proliferation
oxidative stress
endoplasmic reticulum stress
endothelial cells
cell death
vascular endothelial growth factor
cell cycle arrest
mass spectrometry
wound healing
network analysis