Insights from a multicenter study on adult H3 K27M-mutated glioma: Surgical resection's limited influence on overall survival, ATRX as molecular prognosticator.
Alice RybaZeynep ÖzdemirNitzan NissimovLisa HöniklNicolas NeidertMartin JakobsDarius KalasauskasAleksandrs KrigersClaudius ThoméChristian F FreyschlagFlorian RingelAndreas UnterbergPhilip Dao TrongJürgen BeckDieter Henrik HeilandBernhard MeyerPeter VajkoczyJulia OnkenWalter StummerEric Suero MolinaJens GemptManfred WestphalUlrich SchüllerMalte MohmePublished in: Neuro-oncology (2024)
The present study describes surgical features of H3 K27M-mutated glioma in adulthood in a large multicentric study. Our data reveal that ATRX status, location and KPS significantly impact OS in H3 K27M-mutated glioma. Importantly, our dataset indicates that resection does not offer a survival advantage over biopsy.