Laser Capture Microscopy RNA Sequencing for Topological Mapping of Synovial Pathology During Rheumatoid Arthritis.
Benjamin Van EspenE Barton PrideauxAndrew R WilsonCamilla R L MachadoSho SendoJames ParkerGrégory SeumoisCristiano SacchettiAnna C BelongiaNarayanan B PerumalPandurangan VijayanandMatthew D LinnikRobert J BenschopWei WangNunzio BottiniGary S FiresteinStephanie M StanfordPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2024)
LCM-RNAseq confirms reported transcriptional differences between the RA synovium and the OA synovium and provides evidence supporting a relationship between synovial topology and molecular anomalies in RA.
Keyphrases
- rheumatoid arthritis
- disease activity
- high resolution
- single molecule
- high speed
- ankylosing spondylitis
- single cell
- interstitial lung disease
- gene expression
- systemic lupus erythematosus
- transcription factor
- knee osteoarthritis
- high density
- label free
- mass spectrometry
- heat shock
- systemic sclerosis
- idiopathic pulmonary fibrosis