Effective Therapy of Drug-Resistant Bacterial Infection by Killing Planktonic Bacteria and Destructing Biofilms with Cationic Photosensitizer Based on Phosphindole Oxide.
Jianqing LiZijuan MengZeyan ZhuangBingnan WangJun DaiGuangxue FengXiaoding LouFan XiaZhujin ZhaoBen Zhong TangPublished in: Small (Weinheim an der Bergstrasse, Germany) (2022)
Developing effective therapies to fight against biofilm-associated infection is extremely urgent. The complex environment of biofilm forces the bacteria to evade the elimination of antibiotics, resulting in recalcitrant chronic infections. To address this issue, a cationic antibacterial agent based on phosphindole oxide (β-PM-PIO) is designed and prepared. The unique molecular structure endows β-PM-PIO with aggregation-induced emission feature and efficient singlet oxygen generation ability. β-PM-PIO shows excellent visual diagnostic function to planktonic bacteria and biofilm. In addition, owing to the synergistic effect of phototoxicity and dark toxicity, β-PM-PIO can achieve superb antibacterial and antibiofilm performance against Gram-positive bacteria with less potential of developing drug resistance. Notably, β-PM-PIO also holds excellent anti-infection capacity against drug-resistant bacteria in vivo with negligible side effects. This work offers a promising platform to develop advanced antibacterial agents against multidrug-resistant bacterial infection.
Keyphrases
- drug resistant
- multidrug resistant
- particulate matter
- acinetobacter baumannii
- air pollution
- gram negative
- pseudomonas aeruginosa
- candida albicans
- polycyclic aromatic hydrocarbons
- staphylococcus aureus
- heavy metals
- klebsiella pneumoniae
- silver nanoparticles
- biofilm formation
- machine learning
- anti inflammatory
- risk assessment
- essential oil
- climate change
- single cell
- cell therapy
- human health