Influence of CYP2C9, VKORC1, and CYP4F2 polymorphisms on the pharmacodynamic parameters of warfarin: a cross-sectional study.

Kannan SridharanRashed Al BannaZainab MalallaAysha HusainMai SaterGhufran JassimSameer Otoom

Published in: Pharmacological reports : PR (2021)

The evaluated genetic polymorphisms significantly influenced all the pharmacodynamic parameters of warfarin. Evaluating CYP2C9, VKORC1, and CYP4F2 genetic polymorphisms prior to warfarin initiation is likely to optimize therapeutic response.

Keyphrases

atrial fibrillation
direct oral anticoagulants
venous thromboembolism
oral anticoagulants
physical activity