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Granulocyte Apheresis: Can It Be Associated with Anti PD-1 Therapy for Melanoma?

Alvise SernicolaAnna ColpoAnca Irina LeahuMauro Alaibac
Published in: Medicina (Kaunas, Lithuania) (2022)
In the field of advanced melanoma, there is an urgent need to investigate novel approaches targeting specific components of the cancer-immunity cycle beyond immune checkpoint inhibitors. The authors reviewed the basic understanding of the role of neutrophils in cancer biology, and the latest clinical evidence supporting the correlation between cancer-associated neutrophils and the prognosis and response to the immunotherapy of advanced melanoma. Finally, they propose that granulocyte and monocyte apheresis, an emerging non-pharmacological treatment in current dermatology, could become an investigative treatment targeting melanoma-associated neutrophils which could be potentially used in combination with the usual immune checkpoint inhibitors.
Keyphrases
  • papillary thyroid
  • skin cancer
  • peripheral blood
  • dendritic cells
  • basal cell carcinoma
  • squamous cell carcinoma
  • drug delivery
  • replacement therapy
  • childhood cancer