Immunologic Assessment of Tumors from a Race-matched Military Cohort Identifies Mast Cell Depletion as a Marker of Prostate Cancer Progression.

Cara C Schafer Jiji Jiang Sally Elsamanoudi Darryl Nousome Denise Y Young Yingjie Song Isabell A Sesterhenn Gregory T Chesnut Shyh-Han Tan

Published in: Cancer research communications (2023)

Our findings demonstrate that there are immune-related genes and pathways that differ by race. Impaired intratumoral cellular immune composition, especially for TIL-normalized mast cells, may be vital in predicting and contributing to prostate cancer disease progression.

Keyphrases

prostate cancer
radical prostatectomy
genome wide
dna methylation
gene expression
posttraumatic stress disorder