Invariant natural killer T cells are functionally impaired in patients with systemic sclerosis.

Ann-Christin PecherFelix KettemannElisa AsteritiHannes SchmidSilke Duerr-StoerzerHildegard KeppelerJoerg Christoph HenesReinhild KleinClemens HinterleitnerKathy-Ann SeckerCorina SchneidawindLothar KanzDominik Schneidawind

Published in: Arthritis research & therapy (2019)

iNKT cells are deficient and functionally impaired in patients with SSc. Therefore, adoptive transfer strategies using culture-expanded iNKT cells could be a novel approach to treat SSc patients.

Keyphrases

systemic sclerosis
induced apoptosis
cell cycle arrest
interstitial lung disease
newly diagnosed
ejection fraction
endoplasmic reticulum stress
stem cells
signaling pathway
rheumatoid arthritis
cell therapy
prognostic factors
oxidative stress
cell proliferation