Investigation of the relationships between knee osteoarthritis and obesity via untargeted metabolomics analysis.
Onur SenolGulsah GundogduKoksal GundogduFatma Demirkaya MilogluPublished in: Clinical rheumatology (2019)
Acid concentration and oxidative stress agents were high in inflammation group and their levels were much higher in obesity. It is claimed that obesity cause oxidative stress and acidosis in arthritis patients. Valine was found to be the only BCAA molecule whose concentration has significantly different in KOA patients. The relation between KOA and obesity was firstly investigated with metabolomics method.
Keyphrases
- oxidative stress
- insulin resistance
- end stage renal disease
- metabolic syndrome
- knee osteoarthritis
- weight loss
- type diabetes
- chronic kidney disease
- ejection fraction
- high fat diet induced
- mass spectrometry
- newly diagnosed
- weight gain
- prognostic factors
- peritoneal dialysis
- dna damage
- rheumatoid arthritis
- adipose tissue
- body mass index
- diabetic rats
- signaling pathway