Ginsenoside Rg5 induces NSCLC cell apoptosis and autophagy through PI3K/Akt/mTOR signaling pathway.
Caidie ZhangYan JinPublished in: Human & experimental toxicology (2024)
Rg5 induced autophagy and caspase-dependent apoptosis in NSCLC cells by inhibiting the PI3K/Akt/mTOR signaling pathway, suggesting that Rg5 might become a promising and novel anti-tumor agent for the clinical treatment of NSCLC patients.
Keyphrases
- signaling pathway
- induced apoptosis
- endoplasmic reticulum stress
- cell cycle arrest
- pi k akt
- cell death
- small cell lung cancer
- oxidative stress
- advanced non small cell lung cancer
- end stage renal disease
- epithelial mesenchymal transition
- ejection fraction
- newly diagnosed
- chronic kidney disease
- prognostic factors
- brain metastases
- cell proliferation
- peritoneal dialysis
- diabetic rats
- drug induced
- patient reported outcomes
- patient reported
- smoking cessation
- tyrosine kinase