Clinical Importance of FNDC-5 and Selectin-E mRNA Expression Among Type 2 Diabetics with and without Obesity.

Amit K VermaAlanoud I Aladel Sadaf Dabeer Irfan Ahmad AnsariMohammad Idreesh KhanMalak Ghazi AlmutairiAlhanouf I Al-Harbi Mirza Masroor Ali Beg

Published in: Diabetes, metabolic syndrome and obesity : targets and therapy (2022)

FNDC-5 down regulation was observed with T2DM with obesity, vitamin-D and vitamin-B12 deficiency suggesting obesity, vitamin-D and vitamin-B12 deficiency could be the factor for FNDC-5 down-regulation leading to worseness or progression of disease. We suggest that FNDC-5 down-regulation could be used as an indicator for T2DM worseness and development of other associated complications.

Keyphrases

insulin resistance
metabolic syndrome
weight loss
high fat diet induced
type diabetes
weight gain
glycemic control
risk factors
replacement therapy