Single-cell transcriptomics reveals the effect of PD-L1/TGF-β blockade on the tumor microenvironment.

Yoong Wearn LimGarry L ColesSavreet K SandhuDavid S JohnsonAdam S AdlerErica L Stone

Published in: BMC biology (2021)

Taken together, our data could be leveraged translationally to complement or find alternatives to anti-PD-L1 plus anti-TGF-β combination therapy, for example through companion biomarkers, and/or to identify novel targets that could be modulated to overcome resistance.

Keyphrases

single cell
transforming growth factor
rna seq
high throughput
machine learning