Sinoflavonoids NJ and NK, anti-inflammatory prenylated flavonoids from the fruits of Podophyllum hexandrum Royle.

Junyang WangHan LiYanhui LiAiping YangSheng BaoYuntian ZhangQing DuZongping ZhengXia-Chang Wang

Published in: Natural product research (2023)

Two new prenylated flavonoids named sinoflavonoids NJ and NK ( 1 - 2 ), along with ten known compounds were isolated from the fruits of Podophyllum hexandrum Royle. The chemical structures were determined through NMR spectroscopic data and MS analysis. Sinoflavonoid NJ ( 1 ) with an unusual 5,11-dioxabenzo[ b ]fluoren-10-one skeleton was firstly reported from Berberidaceae. The isolated flavonoids were tested with LPS-induced RAW 264.7 mouse macrophages model for their anti-inflammatory activity. Sinoflavonoid NJ ( 1 ) showed the most potent inhibition on nitric oxide production with IC 50 value as 0.06 μ M.

Keyphrases

lps induced
anti inflammatory
nitric oxide
inflammatory response
high resolution
magnetic resonance
mass spectrometry
multiple sclerosis
nk cells
electronic health record
ms ms
nitric oxide synthase
big data
hydrogen peroxide
data analysis
machine learning