Development of Highly Optimized Antibody-Drug Conjugates against CD33 and CD123 for Acute Myeloid Leukemia.

Yoon-Chi HanJennifer Kahler Nicole M Piche-NicholasWenyue HuStephane ThibaultFan JiangMauricio LealMadan KatragaddaAndreas MadernaRussell DushinNadira PrashadManoj B CharatiTracey ClarkL Nathan TumeyXingzhi TanAndreas GiannakouEdward RosfjordHans-Peter GerberLioudmila TchistiakovaFrank Loganzo Christopher J O'DonnellPuja Sapra

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

We optimized all components of ADC design (i.e., leukemia antigen, antibody, and linker-payload) to develop an ADC that has the potential to translate into an effective new therapy against AML.

Keyphrases

acute myeloid leukemia
allogeneic hematopoietic stem cell transplantation
diffusion weighted imaging
diffusion weighted
nk cells
bone marrow
stem cells
computed tomography
contrast enhanced
magnetic resonance imaging
human health
mesenchymal stem cells
cancer therapy
drug delivery
acute lymphoblastic leukemia