Plasmodium falciparum malarial parasites from Brazil lack artemisinin resistance-associated mutations in the kelch13 gene.

Francesca ChapadenseRicardo Luiz Dantas MachadoAna Maria Revorêdo da Silva VenturaAndré ÁreasRenato Beilner MachadoGiselle Rachid VianaMariano Gustavo ZalisAna Maria de CastroPedro Cravo

Published in: Revista da Sociedade Brasileira de Medicina Tropical (2019)

Although the sample size is relatively small, these results suggest that P. falciparum artemisinin-resistant mutants do not exist in Brazil, thereby supporting the continuation of current treatment programs based on artemisinin-based combination therapy.

Keyphrases

plasmodium falciparum
combination therapy
genome wide
copy number
gene expression
wild type