Integrated analyses of 5 mC, 5hmC methylation and gene expression reveal pathology-associated AKT3 gene and potential biomarkers for Alzheimer's disease.

Yupei ShenWeiqiang ZhuShuaicheng LiZhaofeng ZhangJian ZhangMingjie LiWei ZhengDifei WangYushun ZhongMin LiHuajun ZhengJing Du

Published in: Journal of psychiatric research (2024)

AKT3 and MBP may be associated with AD pathology and could serve as biomarkers. The ten predicted chemicals might offer new therapeutic approaches. Our findings could contribute to identifying novel markers and advancing the understanding of AD mechanisms.

Keyphrases

genome wide
gene expression
dna methylation
signaling pathway
cell proliferation
copy number
cognitive decline
single cell
genome wide identification
transcription factor