Association between PIRCHE-II scores and de novo allosensitization after reduction of immunosuppression during SARS-CoV-2 infection in kidney transplant recipients.
Kai Castrezana-LopezRonja MalchowJakob NilssonSanna M KokkonenElena RhoSeraina von MoosThomas F MuellerThomas SchachterPublished in: Transplant infectious disease : an official journal of the Transplantation Society (2023)
Our data show that the HLA-derived epitope mismatch load between donor and recipient influences the risk of de novo DSA development when immunosuppression is temporarily reduced. Our data further suggest that reduction in immunosuppression should be made more cautiously in KTRs with high PIRCHE-II scores for HLA-class II antigens.