Loss of the Incretin Effect in Type 2 Diabetes: A Systematic Review and Meta-analysis.
Eleonora GrespanAnnamaria GuoloElza MuscelliEleuterio FerranniniAndrea MariPublished in: The Journal of clinical endocrinology and metabolism (2022)
The IE impairment in T2D vs NGT is consistent though considerably variable, age being a possible factor affecting the IE difference. Glucose tolerance, BMI, and fasting GIP are independently associated with IE; in subjects with T2D only, the OGTT dose is a significant covariate.