Metastatic melanoma: pretreatment contrast-enhanced CT texture parameters as predictive biomarkers of survival in patients treated with pembrolizumab.
Carole DurotSébastien MuléPhilippe SoyerAude MarchalFlorent GrangeChristine HoeffelPublished in: European radiology (2019)
• Pretreatment skewness at coarse texture scale in metastases from malignant melanoma was an independent predictor of overall survival and progression-free survival. • Skewness values above -0.55 at coarse texture scale were significantly associated with both lower OS and lower PFS after administration of pembrolizumab. • In patients with metastatic MM, texture analysis performed on pretreatment CT may act as a useful tool to select the best candidates for pembrolizumab therapy.
Keyphrases
- contrast enhanced
- free survival
- diffusion weighted
- magnetic resonance imaging
- computed tomography
- magnetic resonance
- advanced non small cell lung cancer
- diffusion weighted imaging
- molecular dynamics
- dual energy
- molecular dynamics simulations
- tyrosine kinase
- bone marrow
- mesenchymal stem cells
- replacement therapy
- data analysis