Palladium-catalyzed C(sp 3 )-H nitrooxylation of masked alcohols.

A palladium-catalyzed β-C(sp 3 )-H nitrooxylation of aliphatic alcohols with AgNO 2 is reported. An 8-formylquinoline-derived oxime is installed as an exo -type directing group for sp 3 C-H activation and selectfluor acts as the oxidant. The reaction tolerates a variety of functional groups and shows good selectivity for β-C-H nitrooxylation of alcohols.