Hybrid PET-MRI Imaging in Paediatric and TYA Brain Tumours: Clinical Applications and Challenges.
Ananth ShankarJamshed BomanjiHarpreet HyarePublished in: Journal of personalized medicine (2020)
(1) Background: Standard magnetic resonance imaging (MRI) remains the gold standard for brain tumour imaging in paediatric and teenage and young adult (TYA) patients. Combining positron emission tomography (PET) with MRI offers an opportunity to improve diagnostic accuracy. (2) Method: Our single-centre experience of 18F-fluorocholine (FCho) and 18fluoro-L-phenylalanine (FDOPA) PET-MRI in paediatric/TYA neuro-oncology patients is presented. (3) Results: Hybrid PET-MRI shows promise in the evaluation of gliomas and germ cell tumours in (i) assessing early treatment response and (ii) discriminating tumour from treatment-related changes. (4) Conclusions: Combined PET-MRI shows promise for improved diagnostic and therapeutic assessment in paediatric and TYA brain tumours.
Keyphrases
- positron emission tomography
- computed tomography
- magnetic resonance imaging
- contrast enhanced
- pet ct
- diffusion weighted imaging
- pet imaging
- intensive care unit
- emergency department
- end stage renal disease
- ejection fraction
- young adults
- magnetic resonance
- resting state
- white matter
- prognostic factors
- multiple sclerosis
- brain injury
- palliative care
- machine learning
- artificial intelligence
- cerebral ischemia
- blood brain barrier
- patient reported
- deep learning