Pro-Apoptotic Effects of Estetrol on Long-Term Estrogen-Deprived Breast Cancer Cells and at Low Doses on Hormone-Sensitive Cells.

Wei YueCarole VerhoevenHerjan Coelingh BernninkJi-Ping WangRichard J Santen

Published in: Breast cancer : basic and clinical research (2019)

The pro-apoptotic effects of E4 and E3 on LTED cells and at low doses on MCF-7 cells indicate that these steroids could be used as therapeutic agents for endocrine-resistant or sensitive breast cancer.

Keyphrases

induced apoptosis
cell cycle arrest
cell death
breast cancer cells
anti inflammatory
endoplasmic reticulum stress
signaling pathway
oxidative stress
pi k akt