Inhibition of HSPA8 by rifampicin contributes to ferroptosis via enhancing autophagy.
Juan ZhouYingzheng TanLingli HuJingli FuDan LiJun ChenYunzhu LongPublished in: Liver international : official journal of the International Association for the Study of the Liver (2022)
The present study highlights the crucial roles of the HSPA8 and autophagy in ferroptotic cell death driving by rifampicin, particularly illumines multiple promising regulatory nodes for therapeutic interventions in diseases involving AT-DILI.