Enhanced chromatin accessibility contributes to X chromosome dosage compensation in mammals.

Irene TalonAdrian JaniszewskiBart TheeuwesThomas LefevreJuan SongGreet BervoetsLotte VanheerNatalie De GeestSuresh PoovathingalRyan AllsopJean-Christophe MarineFlorian RambowThierry VoetVincent Pasque

Published in: Genome biology (2021)

Our data reveal the existence of intrinsic compensatory mechanisms that involve modulation of chromatin accessibility to counteract X-to-Autosome gene dosage imbalances caused by evolutionary or in vitro X chromosome loss and X chromosome inactivation in mammalian cells.

Keyphrases

genome wide
copy number
dna methylation
gene expression
dna damage
transcription factor
electronic health record
big data
single cell
oxidative stress