Glycosphingolipids of porcine, bovine, and equine pericardia as potential immune targets in bioprosthetic heart valve grafts.
Angela BaroneJohn BenktanderChristy WhiddonChunsheng JinCesare GalliSusann TenebergMichael E BreimerPublished in: Xenotransplantation (2018)
Several carbohydrate antigens which are potential targets for the human immune system have been identified in the animal pericardial tissues used for the production of BHV. Which of these antigens are left in the tissues after industrial BHV production processes, as well as their potential role in eventual BHV degradation, remains to be elucidated.
Keyphrases
- aortic valve
- mitral valve
- gene expression
- endothelial cells
- dendritic cells
- heart failure
- transcatheter aortic valve replacement
- human health
- aortic valve replacement
- heavy metals
- aortic stenosis
- induced pluripotent stem cells
- risk assessment
- immune response
- transcatheter aortic valve implantation
- coronary artery disease
- climate change