Efficient Buchwald-Hartwig-Migita Cross-Coupling for DNA Thioglycoconjugation.
Nicolas ProbstRémy LartiaOcéane ThéryMouâd AlamiEric DefrancqSamir MessaoudiPublished in: Chemistry (Weinheim an der Bergstrasse, Germany) (2018)
An efficient method for the thioglycoconjugation of iodinated oligonucleotides by Buchwald-Hartwig-Migita cross-coupling under mild conditions is reported. The method enables divergent synthesis of many different functionalized thioglycosylated ODNs in good yields, without affecting the integrity of the other A, C, and G nucleobases.