Integrative blood-derived epigenetic and transcriptomic analysis reveals the potential regulatory role of DNA methylation in ankylosing spondylitis.
Min XiaoXuqi ZhengXiaomin LiXinyu WuYefei HuangQiujing WeiShuangyan CaoJie-Ruo GuPublished in: Arthritis research & therapy (2022)
Our studies outlined the landscapes of epi-signatures of AS and several methylation-gene expression-AS regulatory axis and highlighted the Th17 cell differentiation and TCR signaling pathway, which might provide innovative molecular targets for therapeutic interventions for AS.
Keyphrases
- dna methylation
- ankylosing spondylitis
- gene expression
- genome wide
- signaling pathway
- transcription factor
- disease activity
- rheumatoid arthritis
- pi k akt
- regulatory t cells
- copy number
- physical activity
- systemic lupus erythematosus
- epithelial mesenchymal transition
- induced apoptosis
- oxidative stress
- network analysis
- cell proliferation