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Strong concordance between percent inhibition in oocyst and sporozoite intensities in a Plasmodium falciparum standard membrane-feeding assay.

Kazutoyo MiuraBruce J SwihartBingbing DengLuwen ZhouThao P PhamAbabacar DioufMichael P FayCarole A Long
Published in: Parasites & vectors (2019)
The results indicate that percent inhibition in oocyst intensity of a test sample can be directly converted to % inhibition in sporozoite intensity in P. falciparum SMFA. Therefore, if sporozoite intensity determines transmission rate from mosquitoes to humans, the percent inhibition in oocyst intensity measured by SMFA can be used to estimate the TBV efficacy.
Keyphrases
  • high intensity
  • plasmodium falciparum
  • high throughput
  • dengue virus
  • single cell