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Screened α-Helix Peptide Inhibitor toward SARS-CoV-2 by Blocking a Prion-like Domain in the Receptor Binding Domain.

Shang WuLimin ZhangWeizhi Wang
Published in: Analytical chemistry (2022)
A new peptide inhibitor was designed and optimized from an α-helix-rich peptide library specifically toward the critical prion-like domain (PLD) of SARS-CoV-2. It compactly blocked the S1 protein and potently neutralized the pseudovirus which shows promising potential for prophylactic and treatment of COVID-19.
Keyphrases
  • sars cov
  • respiratory syndrome coronavirus
  • dna binding
  • coronavirus disease
  • risk assessment
  • human health
  • transcription factor
  • climate change
  • smoking cessation