TiO 2 /Polystyrene Nanocomposite Antibacterial Material as a Hemoperfusion Adsorbent for Efficient Bilirubin Removal and Prevention of Bacterial Infection.
Yunzheng DuMengya ChenBiao WangYamin ChaiLichun WangNan LiYanjia ZhangZhuang LiuChen GuoXinbang JiangBoya MaZimeng WangZiying TianLailiang OuPublished in: ACS biomaterials science & engineering (2024)
The use of hemoperfusion adsorbents for the removal of bilirubin in patients with liver failure has become a critical treatment. However, the insufficient clearance of bilirubin and the possibility of bacterial infection during hemoperfusion limit the application. In this work, we designed a novel antibacterial bilirubin adsorbent (PSVT) through the suspension polymerization reaction between double-bond functionalized TiO 2 nanoparticles and styrene. PSVT showed an excellent bilirubin adsorption ability and antibacterial performance, ensuring efficient clearance of bilirubin in liver failure patients during hemoperfusion and preventing bacterial infection. The experimental results indicated that TiO 2 was uniformly dispersed in the microspheres, which improved the mesoporous structure and increased the specific surface area. Composite adsorbent PSVT showed an exceptional bilirubin adsorption capacity, with the maximum adsorption capacity reaching 24.3 mg/g. In addition, the introduction of TiO 2 endowed PSVT with excellent antibacterial ability; the ultimate antibacterial rates against Escherichia coli and Staphylococcus aureus reached 97.31 and 96.47%, respectively. In summary, PSVT served as a novel antibacterial bilirubin adsorbent with excellent bilirubin clearance capacity and antibacterial performance, providing excellent application prospects for treating liver failure patients.
Keyphrases
- liver failure
- aqueous solution
- silver nanoparticles
- hepatitis b virus
- end stage renal disease
- escherichia coli
- quantum dots
- staphylococcus aureus
- ejection fraction
- newly diagnosed
- chronic kidney disease
- prognostic factors
- anti inflammatory
- solid phase extraction
- essential oil
- septic shock
- wound healing
- peritoneal dialysis
- cystic fibrosis
- gold nanoparticles
- high resolution
- multidrug resistant
- candida albicans
- smoking cessation